Neuroscience · Spatial Biology · Data Science

Nice to meet you.
I'm Jim.

I'm an interdisciplinary scientist who's spent a decade moving between the bench, the microscope, and the codebase — currently building the next generation of spatial biology instruments in San Jose, CA.

Jim McBurney-Lin Santa Cruz Mountains, CA
About

From tide pools to trail runs.

Born in Singapore, I moved to the Santa Cruz mountains in the second grade. I graduated from Los Gatos High School and went south to pursue a degree in Physiology and Neuroscience at UC San Diego. After completing my studies, I joined a local biotech firm, Diazyme, to help develop and test clinical diagnostic assays.

In 2016, I returned to academia to begin my PhD at UC Riverside. My research focused on the role of the noradrenergic nucleus, the locus coeruleus, in behavioral flexibility — a significant part of my effort went into building custom data acquisition rigs, designing novel behavioral paradigms, and building pipelines to analyze large-scale, multi-modal datasets.

Since then, I've carried that same curiosity into industry — first developing rapid imaging workflows at Akoya Biosciences, and now leading applications engineering for spatial genomics instrumentation at Acuity.

As a more outdoorsy-than-indoorsy type, I enjoy running, biking, surfing, and golfing my way around the Santa Cruz mountains — usually with my two dogs, Bear and Molly, close behind.
Experience

The path so far

A career, like a good trail, rarely runs in a straight line. Here's the route from the lab bench to the instrument floor.

now
Senior Applications DVT Engineer — Acuity Spatial Genomics current
San Jose, CA · December 2023 – Present
  • Leading the effort to test and qualify assay automation hardware and software
  • Developing novel analysis pipelines for assay, hardware, and software test routines
  • Collaborating with hardware and software development teams to design new, innovative features and improvements
  • Collaborating with the assay development team to optimize the intersection of assay performance and hardware performance
'22
Scientist I → Scientist II — Akoya Biosciences
Menlo Park, CA · April 2022 – December 2023
  • Led a team developing novel rapid-throughput workflows on the PhenoCycler-Fusion, an automated staining and whole-slide scanning instrument
  • Developed and validated image analysis routines to assess staining and imaging quality
  • Designed and implemented novel automation routines to improve workflow
  • Assisted in the development of hardware and software improvements
'16
Graduate Researcher, PhD — University of California, Riverside
Riverside, CA · September 2016 – March 2022
  • Led a multi-disciplinary team characterizing the role of the locus coeruleus in somatosensory-based rodent behavior
  • Developed a novel animal behavioral assay to elucidate the neural mechanisms of behavioral flexibility
  • Designed custom behavioral apparatuses with simultaneous electrophysiology, pupil diameter tracking, and rodent movement tracking
PhD, Neuroscience
University of California, Riverside
2022
BS, Physiology & Neuroscience
University of California, San Diego
2014
Research

Publications

Work on the locus coeruleus — the brain's noradrenergic hub — and its role in sensory processing and behavioral flexibility.

* denotes co-first authorship

Toolkit

What I work with

Microscopy & Imaging

Confocal microscopy Epifluorescent microscopy Whole-slide scanning Cell imaging & analysis

Molecular Biology

PCR AAV / retroviral transduction Immunostaining RNAscope In-situ hybridization Electrophysiology (tetrode, Neuropixel)

Computational

R Python MATLAB SQL QuPath ImageJ
Recognition

Awards

Off the Clock

Life outside the lab

Trails with Bear and Molly, time in the woodshop, and — more often than not — something happening in the kitchen.

Running in the Santa Cruz Mountains
Trail running, Santa Cruz Mtns
IM 70.3 Santa Cruz
Ironman Santa Cruz 70.3, 2025
SF Marathon!
San Francisco Marathon, 2025
Bear and Molly
Bear and Molly